Harnessing the 'Omics Revolution to Investigate Drug Response and Resistance Mechanisms in Giardia Duodenalis

Grant number: LP120200122 | Funding period: 2012 - 2017

Completed

Abstract

This international research project will harness cutting-edge technologies to explore how Giardia, a major global cause of diarrhoeal illness in humans, responds to and becomes resistant to key anti-giardial drugs, providing valuable information for drug preservation and development.

Related publications (7)

Scholarly works icon

Annotation of the Giardia proteome through structure-based homology and machine learning

BRE Ansell, BJ Pope, P Georgeson, SJ Emery-Corbin, AR Jex

2018-12-06

Background: Large-scale computational prediction of protein structures represents a cost-effective alternative to empirical struct..

Scholarly works icon

Proteomic diversity in a prevalent human-infective Giardia duodenalis sub-species

SJ Emery-Corbin, D Vuong, E Lacey, SG Svärd, BRE Ansell, AR Jex

2018-09-01

Giardia duodenalis a species complex of gastrointestinal protists, with assemblages A and B infective to humans. To date, post-gen..

Scholarly works icon

Differential protein expression and post-translational modifications in metronidazole-resistant Giardia duodenalis

SJ Emery, L Baker, BRE Ansell, M Mirzaei, PA Haynes, MJ McConville, SG Svärd, AR Jex

2018-04-01

Background: Metronidazole (Mtz) is the frontline drug treatment for multiple anaerobic pathogens, including the gastrointestinal p..

Scholarly works icon

Transcriptomics indicates active and passive metronidazole resistance mechanisms in three seminal Giardia lines

BRE Ansell, L Baker, SJ Emery, MJ McConville, SG Svärd, RB Gasser, AR Jex

2017-03-17

Giardia duodenalis is an intestinal parasite that causes 200-300 million episodes of diarrhoea annually. Metronidazole (Mtz) is a ..

Scholarly works icon

Divergent transcriptional responses to physiological and xenobiotic stress in Giardia duodenalis

BRE Ansell, MJ McConville, L Baker, PK Korhonen, SJ Emery, SG Svärd, RB Gasser, AR Jexa

2016-10-01

Understanding how parasites respond to stress can help to identify essential biological processes. Giardia duodenalis is a parasit..

Scholarly works icon

Time-Dependent Transcriptional Changes in Axenic Giardia duodenalis Trophozoites

BRE Ansell, MJ McConville, L Baker, PK Korhonen, ND Young, RS Hall, CAA Rojas, SG Svärd, RB Gasser, AR Jex

2015-12-04

Giardia duodenalis is the most common gastrointestinal protozoan parasite of humans and a significant contributor to the global bu..

Scholarly works icon

Drug resistance in Giardia duodenalis

BRE Ansell, MJ McConville, SY Ma'ayeh, MJ Dagley, RB Gasser, SG Svärd, AR Jex

2015-11-01

Giardia duodenalis is a microaerophilic parasite of the human gastrointestinal tract and a major contributor to diarrheal and post..

University of Melbourne Researchers